Usually , clr is binding to c1inh ( cl inhibitor ) . when immune complex ( ic ) binds to clq , c1inh is detached form clr , and then the serine protease is activated , and then the complement classical pathway is activated 在一般情況下, c1r與c1inh ( c1inhibitor )結(jié)合著,而一旦有免疫復(fù)合物( ic )結(jié)合到c1q上時(shí),浙江大學(xué)碩士學(xué)位論文cllnh的抑制作用即行移除, clr的構(gòu)象發(fā)生改變,具有酶活性,從而啟動(dòng)補(bǔ)體激活經(jīng)典途徑。
The presence of complement - like activity in the humoral fluid of amphioxus was examined . the complement classical pathway ( cp ) activity is assayed by determining the amount of serum required to hemolyse a given number of sensitized sheep red blood cells ( srbc ) , whereas the complement alternative pathway ( ap ) activity measured in the same manner , but by using rabbit red blood cells ( rarbc ) instead of sensitized srbc 文昌魚(yú)體液可溶解懸浮在10mmol legta - mg - gvb緩沖液中的正常的兔血紅細(xì)胞、綿羊紅細(xì)胞、及部分哺乳動(dòng)物、鳥(niǎo)類、兩棲類和魚(yú)類的代表動(dòng)物的血紅細(xì)胞;而在gvb ~ ( 2 + )緩沖液中時(shí)對(duì)抗體包被的綿羊紅細(xì)胞卻沒(méi)有溶血活性。